Question

To inhibit the growth of tumours, identify the compounds used from the following:
(A) EDTA
(B) Coordination Compounds of Pt
(C) D – Penicillamine
(D) Cis – Platin
Choose the correct answer from the options given below:

• A. B and D Only
• B. C and D Only
• C. A and B Only
• D. A and C Only

Hint:

Cisplatin and other platinum-based coordination compounds are effective anticancer drugs. They form cross-links with DNA, disrupting cell division and leading to tumour inhibition.

Answer 1

The Correct Option is A

Step 1: Role of Coordination Compounds of Platinum
- Platinum-based coordination compounds, such as Cisplatin (\(\text{cis-}[\text{Pt}(\text{NH}_3)_2\text{Cl}_2]\)), are widely used in chemotherapy.
- These compounds inhibit tumour growth by binding to DNA and interfering with the replication process.
Step 2: Analysis of the Options
Option A (EDTA): EDTA is primarily a chelating agent used for metal ion sequestration, not for tumour treatment.
Option B (Coordination Compounds of Pt): Correct, as platinum-based compounds are effective in tumour inhibition.
Option C (D -- Penicillamine): Penicillamine is used in chelation therapy for heavy metal poisoning, not for tumours.
Option D (Cisplatin): Correct, as it is a well-known platinum-based anti-cancer drug.
Conclusion: The correct combination is B and D. Therefore, the correct answer is (1) B and D Only.