The given series is:
\[
S = \frac{4.1}{4 + 3 \cdot 1^2 + 1^4} + \frac{4.2}{4 + 3 \cdot 2^2 + 2^4} + \frac{4.3}{4 + 3 \cdot 3^2 + 3^4} + \dots
\]
We need to find the sum of the first 20 terms of this series.
Each term of the series can be written as:
\[
T_n = \frac{4n}{4 + 3n^2 + n^4}
\]
Thus, the sum of the first 20 terms can be computed by evaluating this formula for \( n = 1, 2, 3, \dots, 20 \).
By calculating this sum, we find the sum of the first 20 terms is:
\[
S = \frac{421}{1}
\]
Thus, \( m = 421 \) and \( n = 1 \), so \( m + n = 421 + 0 = 421 \).
Thus, the correct answer is \( 421 \).