Question

Metabolic intermediates provide the backbone for the synthesis of amino acids. Match the metabolic intermediates listed in Column I with their corresponding amino acids given in Column II. \[ \begin{array}{|c|c|} \hline \textbf{Column I} & \textbf{Column II} \\ \hline P. \, (\alpha)-\text{Ketoglutarate} & ii. \, \text{Glutamate} \\ \hline Q. \, \text{Ribose 5-phosphate} & i. \, \text{Histidine} \\ \hline R. \, \text{3-Phosphoglycerate} & v. \, \text{Serine} \\ \hline S. \, \text{Phosphoenolpyruvate} & iii. \, \text{Aspartate} \\ \hline \end{array} \]

• A. ( P-ii; Q-i; R-v; S-iv )
• B. ( P-iii; Q-ii; R-i; S-v )
• C. ( P-iv; Q-iii; R-ii; S-v )
• D. ( P-ii; Q-i; R-iv; S-v )

Hint:

When studying metabolic pathways, focus on the relationships and transformation between different intermediates and their products, as this can aid in understanding complex metabolic networks and their regulation.

Answer 1

The Correct Option is A

The metabolic intermediates are the key precursors for amino acid synthesis. The correct matches are: 
(alpha)-Ketoglutarate (P) is a precursor for Glutamate (ii), which is an important neurotransmitter and a key molecule in nitrogen metabolism. Ribose 5-phosphate (Q) is involved in the biosynthesis of Histidine (i), a basic amino acid synthesized from ribose phosphate in several steps. 
3-Phosphoglycerate (R) is a glycolytic intermediate that leads to the formation of Serine (v), which can further feed into pathways for other amino acids. 
Phosphoenolpyruvate (S) is used in the biosynthesis of Phenylalanine (iv), an essential amino acid that humans must obtain from their diet. Conclusion: This matching underscores the varied roles of metabolic intermediates in the biosynthesis of amino acids, highlighting the complexity of cellular metabolism.