The direction of propagation of an electromagnetic (EM) wave is given by the cross product of the electric field vector (\( \vec{E} \)) and the magnetic field vector (\( \vec{B} \)):
\[
\text{Direction of propagation} \propto \vec{E} \times \vec{B}.
\]
Given:
\[
\vec{E} \, \text{(electric field)} \, \text{is along the negative z-axis} \quad (\vec{E} = -\hat{k}),
\]
\[
\vec{B} \, \text{(magnetic field)} \, \text{is along the positive x-axis} \quad (\vec{B} = \hat{i}).
\]
The cross product \( \vec{E} \times \vec{B} \) is:
\[
\vec{E} \times \vec{B} = (-\hat{k}) \times (\hat{i}).
\]
Using the right-hand rule and the vector cross product rules:
\[
\hat{k} \times \hat{i} = \hat{j}.
\]
Thus:
\[
(-\hat{k}) \times (\hat{i}) = -\hat{j}.
\]
This indicates that the direction of propagation of the EM wave is along the negative y-axis.
Hence, the direction of propagation of the electromagnetic wave is \( \boxed{\text{negative y-axis}} \).