Question

Which of the following drug is used to prevent graft rejection?

• A. Azathioprine
• B. Methotrexate
• C. Rapamycin
• D. Tacrolimus

Hint:

Tacrolimus prevents graft rejection by inhibiting calcineurin, blocking T-cell activation.

Answer 1

The Correct Option is D

Step 1: Understanding Graft Rejection Prevention 
Tacrolimus is an immunosuppressive drug that prevents graft rejection by inhibiting T-cell activation, particularly by blocking calcineurin. 
Step 2: Evaluating the Options 
- Azathioprine: Inhibits purine synthesis, used for immunosuppression, but not as effective as tacrolimus for preventing graft rejection. 
- Methotrexate: An antimetabolite that inhibits cell division, not primarily used for graft rejection prevention. 
- Rapamycin: Inhibits mTOR, used in preventing organ rejection but not the first-line drug. 
- Tacrolimus: Correct, tacrolimus is widely used to prevent organ rejection, particularly for kidney transplants. 
Step 3: Conclusion 
Tacrolimus is the drug of choice for preventing graft rejection.