Question

Which are the host cell membrane receptors that the outer coat protein gp-120 of HIV binds to?

• A. \( \text{CD4 and CCR5} \)
• B. \( \text{Pepsin and adenylyl cyclase} \)
• C. \( \text{IP3 and cytochrome-c} \)
• D. \( \text{Bicoid and nanos} \)

Hint:

HIV targets immune cells by engaging CD4 and CCR5/CXCR4 co-receptors, leading to viral replication.

Answer 1

The Correct Option is A

The gp120 protein of HIV binds to CD4 receptors on immune cells, facilitating viral entry. Co-receptors such as CCR5 or CXCR4 further mediate fusion, allowing HIV to infect T-cells. Other options represent unrelated enzymes or developmental regulators.