Question

Which are the host cell membrane receptors that the outer coat protein gp-120 of HIV binds to?

• A. CD4 and CCR5
• B. CD8 and CXCR4
• C. CD4 and CXCR4
• D. CD8 and CCR5

Hint:

HIV targets CD4 and CXCR4 or CCR5 for cell entry.

Answer 1

The Correct Option is C

HIV binds to the host cell via two primary receptors: CD4 and CXCR4. The gp-120 protein of HIV initially binds to CD4, and then the virus undergoes a conformational change to bind to CXCR4 or CCR5, depending on the type of HIV strain. Thus, the correct answer is (c) CD4 and CXCR4.