Question

Antipsychotic drugs work by blocking post-synaptic dopamine __________ receptors, particularly in the mesolimbic-mesocortical pathway.

• A. \( \text{D4} \)
• B. \( \text{D5} \)
• C. \( \text{D2} \)
• D. \( \text{D1} \)

Hint:

D2 receptor antagonism is central to antipsychotic drug function, balancing dopamine levels in the brain.

Answer 1

The Correct Option is C

Most antipsychotic drugs function by blocking dopamine D2 receptors, reducing dopaminergic hyperactivity. This mechanism mitigates positive symptoms of schizophrenia, such as hallucinations and delusions. Other dopamine receptor subtypes, like D1, D4, and D5, play different roles in neurophysiology.