Question

P2Y12 is a chemoreceptor for adenosine diphosphate (ADP) that:

• A. \( \text{Mediates platelet aggregation} \)
• B. \( \text{Mediates WBC stimulation} \)
• C. \( \text{Binds to clopidogrel reversibly} \)
• D. \( \text{Mediates fibrinolysis} \)

Hint:

P2Y12 inhibitors, like clopidogrel, are used as antiplatelet drugs to prevent cardiovascular events like strokes and heart attacks.

Answer 1

The Correct Option is A

P2Y12 is a G-protein coupled receptor found on platelets that plays a crucial role in platelet aggregation. Upon activation by ADP, it amplifies the platelet activation process, contributing to thrombus formation. Clopidogrel and other P2Y12 inhibitors work by blocking this receptor, preventing excessive platelet aggregation and reducing clot formation.