Question

In a patient with lipoprotein lipase deficiency, which of the following is increased following a fatty meal?

• A. Chylomicron
• B. LDL
• C. HDL
• D. Apo-A

Answer 1

The Correct Option is A

In the context of lipoprotein lipase deficiency, it is crucial to understand the role of lipoprotein lipase in lipid metabolism. Lipoprotein lipase is an enzyme essential for the hydrolysis of triglycerides in chylomicrons and very-low-density lipoproteins (VLDL) into free fatty acids and glycerol, allowing their subsequent uptake by tissues.

When a person consumes a fatty meal, triglycerides are packaged into chylomicrons by the intestines. Under normal circumstances, these chylomicrons are broken down by lipoprotein lipase, allowing fatty acid delivery to adipose tissue and muscle.

In a patient with lipoprotein lipase deficiency, this process is impaired. As a result, after consuming a fatty meal, chylomicrons cannot be efficiently metabolized, leading to an accumulation of chylomicrons in the bloodstream.

The options provided were:

• Chylomicron
• LDL (Low-Density Lipoprotein)
• HDL (High-Density Lipoprotein)
• Apo-A (Apolipoprotein A)

Correct Answer: Chylomicron

Explanation: Due to the deficiency of lipoprotein lipase, the enzymatic breakdown of chylomicrons is blocked, causing their levels to increase in the bloodstream after a fatty meal.