Question

Which enzyme is deficient in Gaucher’s disease?

• A. Hexosaminidase A
• B. Glucocerebrosidase
• C. Alpha-galactosidase A
• D. Sphingomyelinase

Hint:

Mnemonic: “Gaucher = Gluco” for glucocerebrosidase deficiency.

Answer 1

The Correct Option is B

Gaucher’s disease is a lysosomal storage disorder caused by deficiency of the enzyme glucocerebrosidase. This leads to accumulation of glucocerebroside in macrophages, producing Gaucher cells. The other enzymes are associated with different disorders:
- Hexosaminidase A — Tay-Sachs disease
- Alpha-galactosidase A — Fabry disease
- Sphingomyelinase — Niemann-Pick disease