Write the therapeutic use and the animal cell line employed in obtaining any three of the following protein pharmaceuticals:
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Solution and Explanation
(A) Erythropoietin: Therapeutic Use: Erythropoietin is primarily used for the treatment of anemia, especially in patients with kidney disease and those undergoing chemotherapy. Animal Cell Line: The most commonly used animal cell line for production of Erythropoietin is CHO (Chinese Hamster Ovary) cell line.
(B) Herceptin: Therapeutic Use: Herceptin (Trastuzumab) is used for breast cancer therapy, particularly in cases where the cancer cells overexpress the HER2 protein. Animal Cell Line: The production of Herceptin typically involves the CHO cell line.
(C) Interleukin-2: Therapeutic Use: Interleukin-2 is mainly used for treating cancer. Animal Cell Line: The most used cell line for production of Interleukin-2 is CHO cells.
(D) Tissue plasminogen activator (tPA): Therapeutic Use: Tissue plasminogen activator (tPA) is used in treating stroke and dissolves blood clots. Animal Cell Line: tPA is produced using CHO cells.
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Alexia Limited invited applications for issuing 1,00,000 equity shares of ₹ 10 each at premium of ₹ 10 per share.
The amount was payable as follows:- On application ₹ 9 per share (Including premium ₹ 6 per share)
- On allotment ₹ 8 per share (Including premium ₹ 4 per share)
- On first and final call ₹ 3 per share.
Applications were received for 1,50,000 equity shares and allotment was made to the applicants as follows:
Category A: Applicants for 90,000 shares were allotted 70,000 shares.
Category B: Applicants for 60,000 shares were allotted 30,000 shares.
Excess money received on application was adjusted towards allotment and first and final call.
Shekhar, who had applied for 1200 shares failed to pay the first and final call. Shekhar belonged to category B.
Pass necessary journal entries for the above transactions in the books of Alexia Limited. Open calls in arrears and calls in advance account, wherever necessary.