Question

Which of the following true regarding Hemophilia A ?

• A. Serum levels of factor VIII are decreased
• B. Deficiency of factor IX
• C. PT increased
• D. FIT decreased

Answer 1

The Correct Option is A

Hemophilia A is a genetic disorder characterized by a deficiency in clotting factor VIII, which leads to impaired blood clotting. The correct statement from the choices provided is that serum levels of factor VIII are decreased. This is a fundamental aspect of Hemophilia A:

• Serum levels of factor VIII are decreased: Hemophilia A is specifically caused by a deficiency or defect in factor VIII, which is a crucial protein for blood coagulation, resulting in increased bleeding tendencies.
• Deficiency of factor IX: This is related to Hemophilia B, not Hemophilia A. Hemophilia B involves a deficiency in factor IX.
• PT increased: Prothrombin Time (PT) is typically normal in Hemophilia A as it assesses the extrinsic pathway, which does not involve factor VIII. Instead, Activated Partial Thromboplastin Time (APTT) is prolonged in Hemophilia A because it assesses the intrinsic pathway where factor VIII is involved.
• FIT decreased: This statement is not standard terminology in the context of Hemophilia A's diagnosis or characteristics. It might be intended to refer to some test but is not commonly associated with the condition.

The understanding of this genetic disorder helps in its diagnosis and management, focusing on the replacement or functional restoration of factor VIII.