Question

What is the cause of intracorpuscular defects in hemolysis?

• A. Uremic syndrome
• B. PCH
• C. PNH
• D. Portal hypertension

Answer 1

The Correct Option is C

Intracorpuscular defects in hemolysis refer to defects within the red blood cells themselves that lead to their premature destruction. One of the key conditions associated with intracorpuscular hemolysis is Paroxysmal Nocturnal Hemoglobinuria (PNH). PNH is a rare acquired hematopoietic stem cell disorder that results in the production of blood cells that are deficient in certain surface proteins that help protect them from the body’s immune attacks. This deficiency makes red blood cells more susceptible to destruction by the complement system, an important part of the immune system, leading to hemolysis of these defective cells.

The correct answer to the problem is: PNH.

Let's briefly explore the options:

• Uremic syndrome: A condition caused by renal failure affecting multiple body systems, but not primarily causing intracorpuscular hemolysis.
• PCH (Paroxysmal Cold Hemoglobinuria): A rare form of autoimmune hemolytic anemia triggered by cold temperatures, causing extracorpuscular hemolysis.
• PNH: Intracorpuscular defect in hemolysis due to deficiency in protection against complement-mediated destruction.
• Portal hypertension: Not related to intracorpuscular hemolysis; it involves increased blood pressure in the portal venous system, often due to liver disease.