Question

Which of the following is not true about Hydraulic capacitance flow control system used in HPLC?

• A. It can be used only for liquids with low viscosity
• B. It is irrespective of solvent compressibility
• C. It maintains constant flow
• D. It smoothens high-pressure pump pulsations

Answer 1

The Correct Option is A

Step 1: Understanding Hydraulic Capacitance Flow Control - Hydraulic capacitance flow control is used in high-performance liquid chromatography (HPLC) to regulate flow consistency. - It compensates for variations caused by solvent compressibility and pump pulsations, ensuring a stable flow.


Step 2: Evaluating the Options - (A) It can be used only for liquids with low viscosity → Incorrect. This system works efficiently for a wide range of solvent viscosities, not just low-viscosity liquids.
- (B) It is irrespective of solvent compressibility → Correct. The system is designed to handle variations in solvent compressibility.
- (C) It maintains constant flow → Correct. A key feature of the system is to ensure uniform flow rate in HPLC.
- (D) It smoothens high-pressure pump pulsations → Correct. It helps in reducing pressure fluctuations, which improves the accuracy of chromatographic separation.


Step 3: Selecting the Correct Answer - Since hydraulic capacitance flow control is not restricted to low-viscosity liquids, option (A) is the incorrect statement and thus the correct choice.