Question

Which of the following functional groups is a classical isostere for -CH= ?

• A. \( \text{-CH}_2 \)
• B. \( \text{-NH-} \)
• C. \( \text{-N-} \)
• D. \( \text{COOH} \)

Hint:

Isosteric modifications in drug design help enhance biological activity while maintaining molecular function.

Answer 1

The Correct Option is C

Classical isosteres are functional groups that mimic steric and electronic properties. The -N- group serves as a classical isostere for -CH=, as both contribute similar electronic effects while modifying biochemical interactions. Other choices introduce distinct electronic or steric differences.