Question

Which of the following drugs works as a proteasome inhibitor?

• A. \( \text{Nilotinib} \)
• B. \( \text{Infliximab} \)
• C. \( \text{Bortezomib} \)
• D. \( \text{Filgrastim} \)

Hint:

Proteasome inhibitors selectively target cancer cell survival mechanisms, triggering cell death.

Answer 1

The Correct Option is C

Bortezomib is a proteasome inhibitor used in multiple myeloma and mantle cell lymphoma treatment. It disrupts protein degradation pathways, causing apoptosis in cancer cells by preventing the breakdown of pro-apoptotic proteins. Other drugs listed function via alternative mechanisms, not proteasome inhibition.