Question

Which of the following drugs reduces LDL cholesterol by inhibiting an intestinal transport protein?

• A. \( \text{Atorvastatin} \)
• B. \( \text{Cholestyramine} \)
• C. \( \text{Ezetimibe} \)
• D. \( \text{Gemfibrozil} \)

Hint:

Unlike statins, ezetimibe targets cholesterol absorption rather than its synthesis, making it useful for combination therapy.

Answer 1

The Correct Option is C

Ezetimibe lowers LDL cholesterol by inhibiting the Niemann-Pick C1-Like 1 (NPC1L1) protein in the intestines. This protein is responsible for cholesterol absorption, and blocking it reduces cholesterol uptake into the bloodstream. Ezetimibe is often used in combination with statins for enhanced lipid-lowering effects.