Question:

Which of the following antipsychotic drugs works by blocking post-synaptic dopamine D2 receptors, particularly in the mesolimbic-mesocortical pathway?

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Haloperidol is a typical antipsychotic, while others like Clozapine and Risperidone are atypical antipsychotics.
Updated On: Jun 12, 2025
  • Haloperidol
  • Clozapine
  • Olanzapine
  • Risperidone
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The Correct Option is A

Solution and Explanation

Haloperidol is a typical antipsychotic drug that works by blocking the D2 dopamine receptors in the brain, especially in the mesolimbic-mesocortical pathways. This is essential in the management of schizophrenia and other psychotic disorders. Clozapine, Olanzapine, and Risperidone are atypical antipsychotics that have a different mechanism, as they affect multiple neurotransmitter systems, including serotonin and dopamine. Thus, the correct answer is (a) Haloperidol.
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