Question

What does chaperones assist in?

• A. Protein Cleavage
• B. Protein Folding
• C. Protein Degradation
• D. Protein Modification

Answer 1

The Correct Option is B

Chaperones are a class of proteins that play a crucial role in maintaining cellular homeostasis by assisting in the proper folding of other proteins. Proteins must achieve a specific three-dimensional structure to function correctly, and chaperones facilitate this process. They can prevent misfolding and aggregation that might result from complex cellular environments. The correct option is:

Protein Folding

During protein synthesis, chaperones temporarily bind to nascent polypeptide chains or non-native proteins to stabilize their unfolded or partially folded state. This enables proteins to avoid premature folding or interactions until they reach an environment conducive to proper folding. By preventing incorrect interactions, chaperones ensure that proteins achieve their functional conformations efficiently.

Overall, chaperones are vital for cellular health, preventing diseases associated with protein misfolding and aggregation, such as Alzheimer's and Parkinson's.