Question:

A 5-year-old girl was washing her doll with shampoo containing a chemical Rotenone. Her mother notices her in an unconscious state. Which of the following complex is inhibited by the above-mentioned chemical?

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Rotenone inhibits NADH dehydrogenase, disrupting ATP production and leading to cellular dysfunction and toxicity.
Updated On: Mar 24, 2025
  • NADH Dehydrogenase
  • Succinate DH
  • Cytochrome C
  • Cytochrome oxidase
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The Correct Option is A

Solution and Explanation

Rotenone inhibits NADH dehydrogenase in the mitochondrial electron transport chain, disrupting the process of oxidative phosphorylation. This inhibition can lead to cellular energy failure and toxicity, resulting in symptoms like unconsciousness.
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