The energy-momentum relation for a relativistic particle is given by the famous equation:
\[
E^2 = p^2 c^2 + m^2 c^4,
\]
where:
- \( E \) is the total energy of the particle,
- \( p \) is the momentum of the particle,
- \( c \) is the speed of light in a vacuum,
- \( m \) is the rest mass of the particle.
This equation is derived from the special theory of relativity and relates the energy of a particle to both its momentum and its rest mass.
Final Answer: \( E^2 = p^2 c^2 + m^2 c^4 \).