Question

The dihydropyridines block which of the following type of calcium channels?

• A. \( \text{L-type voltage-gated channels} \)
• B. \( \text{T-type voltage-gated channels} \)
• C. \( \text{N-type voltage-gated channels} \)
• D. \( \text{Ligand-gated calcium channels} \)

Hint:

Blocking L-type calcium channels leads to vasodilation, reducing blood pressure and myocardial oxygen demand.

Answer 1

The Correct Option is A

Dihydropyridines selectively inhibit L-type voltage-gated calcium channels, which regulate vascular smooth muscle contraction. These drugs, including nifedipine and amlodipine, are used in treating hypertension and angina. T-type and N-type calcium channels serve different physiological roles and are unaffected by dihydropyridines.