Question:
The best explanation for the absorption of salicylic acid from intestine, despite being ionized is:
The best explanation for the absorption of salicylic acid from intestine, despite being ionized is:
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Drug absorption depends on lipid solubility of the un-ionized form — even 1\% can be enough if the surface area is high.
Updated On: Jun 16, 2025
- High surface area of the drug molecules
- Dissolution of drug
- Availability of 1% of the un-ionized form
- Availability of receptors
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The Correct Option is C
Solution and Explanation
Only the un-ionized form of a weak acid like salicylic acid is absorbed effectively across the lipid membrane. Even though the majority is ionized in the intestine, a small fraction (1%) remains un-ionized and allows for absorption.
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