Question

Lipinski’s rule of five is linked with ____.

• A. drug’s metabolic pathway
• B. potency of drug-receptor binding
• C. drug-likeness for oral bioavailability
• D. stability under acidic conditions

Hint:

Lipinski's rule helps filter drug candidates early in the development process based on oral absorption potential.

Answer 1

The Correct Option is C

Lipinski's rule of five predicts the oral bioavailability of a drug candidate based on molecular properties. The rule suggests that good oral drugs generally have no more than one violation among these: not more than 5 hydrogen bond donors, 10 hydrogen bond acceptors, molecular weight under 500 Da, and logP not greater than 5.