Question

What role does the P-glycoprotein efflux pump play in drug absorption?

• A. Enhances metabolism
• B. Inhibits absorption
• C. Facilitates absorption
• D. Has no effect on absorption

Hint:

P-gp = drug efflux pump → reduces absorption → lowers bioavailability.

Answer 1

The Correct Option is B

P-glycoprotein (P-gp) is an efflux transporter found in intestinal epithelium that pumps drugs back into the intestinal lumen, thereby reducing their absorption and bioavailability.