Question

Systemic clearance (CLs) is related with:

• A. \( \text{Only the concentration of substances in plasma} \)
• B. \( \text{Only the elimination rate constant} \)
• C. \( \text{Volume of distribution, half-life, and elimination rate constant} \)
• D. \( \text{Bioavailability and half-life} \)

Hint:

Clearance measures the body's ability to eliminate a drug, influencing dosing and frequency.

Answer 1

The Correct Option is C

Systemic clearance (CL\(_s\)) is determined by the volume of distribution (V\(_d\)), half-life (t\(_{1/2}\)), and elimination rate constant (k). It quantifies how efficiently the body removes a drug, defined as: \[ CL_s = V_d \times k \] This relationship allows pharmacologists to calculate drug dosing and elimination kinetics.