Question

Non-linear pharmacokinetics is most likely due to _____.

• A. first-pass metabolism
• B. saturation of metabolic enzymes
• C. renal excretion
• D. high plasma protein binding

Hint:

Saturation of enzymes → metabolism can't keep up → non-linear kinetics.

Answer 1

The Correct Option is B

Non-linear pharmacokinetics often arises when drug concentrations saturate enzymes responsible for metabolism, resulting in a disproportionate increase in drug levels with dose.