Question

Reed sternberg cells are found in

• A. Hodgkin's disease
• B. Sickle cell anaemia
• C. Thalassemia
• D. CML

Answer 1

The Correct Option is A

Reed-Sternberg cells are a distinctive type of large abnormal lymphocyte that can be found under a microscope in patients with Hodgkin's disease, which is a type of lymphoma or lymphatic system cancer. These cells are considered a characteristic feature necessary for the diagnosis of Hodgkin's disease. Hodgkin's disease, named after Thomas Hodgkin who first described abnormalities in the lymphatic system, is marked by the presence of these Reed-Sternberg cells in lymph nodes. They are typically multinucleated or have a bilobed nucleus, each lobe containing nuclear inclusion-like nucleoli. Identification of these cells is crucial, as Hodgkin's disease has different prognostic outcomes and treatment plans compared to other conditions listed in the options, such as:

• Sickle cell anaemia: A genetic blood disorder causing red blood cells to be misshapen.
• Thalassemia: A genetic disorder affecting hemoglobin, leading to anemia.
• CML (Chronic Myeloid Leukemia): A type of cancer that affects white blood cells not associated with Reed-Sternberg cells.

Thus, Reed-Sternberg cells are uniquely associated with Hodgkin's disease.