Question

Recently, ranitidine and metformin were in the news due to the presence of which impurity?

• A. \( \text{Nitrosodimethylamine} \)
• B. \( \text{Methylnitrile} \)
• C. \( \text{Diethylene glycol} \)
• D. \( \text{4-aminobiphenyl} \)

Hint:

Regulatory agencies conduct impurity screening to prevent carcinogenic contamination in pharmaceuticals.

Answer 1

The Correct Option is A

Nitrosodimethylamine (NDMA) contamination in ranitidine and metformin raised global health concerns. NDMA is classified as a probable human carcinogen, leading to recalls and regulatory reviews. The presence of this impurity in medications is closely monitored to ensure drug safety.