Question

Match the following

• A. A-III, B-V, C-IV, D-II
• B. A-III, B-V, C-I, D-II
• C. A-II, B-I, C-V, D-III
• D. A-I, B-II, C-IV, D-V

Hint:

Remember the genetic basis for common human genetic disorders: Sickle cell anemia is a point mutation, Klinefelter syndrome is XXY, Turner syndrome is XO, and Down syndrome is Trisomy 21.

Answer 1

The Correct Option is B

Step 1: Understand the genetic basis of each disorder

• Sickle cell anaemia: A genetic blood disorder caused by a single nucleotide substitution (point mutation) in the gene encoding the beta-globin chain.
• Klinefelter syndrome: A chromosomal condition in males caused by an extra X chromosome, resulting in 47, XXY karyotype.
• Turner syndrome: A chromosomal condition in females caused by the absence of one X chromosome, resulting in 45, X karyotype.
• Down syndrome: A chromosomal disorder caused by an extra copy of chromosome 21 (trisomy 21).

Step 2: Match each disorder with its genetic characteristic

• A) Sickle cell anaemia: III. Point mutation
• B) Klinefelter syndrome: V. 47, XXY
• C) Turner syndrome: I. 45, X
• D) Down syndrome: II. Trisomy of chromosome 21

Step 3: Compare matches with given options

Our matches: A-III, B-V, C-I, D-II

• (1) A-III, B-V, C-IV, D-II - Incorrect (C is incorrect)
• (2) A-III, B-V, C-I, D-II - Correct (matches perfectly)
• (3) A-II, B-I, C-V, D-III - Incorrect
• (4) A-I, B-II, C-IV, D-V - Incorrect

The final answer is option 2.