Question

Marked bleeding is seen in which of following conditions ?

• A. VMA disease
• B. Haemophilia A
• C. Haemophilia B
• D. ALL

Answer 1

The Correct Option is D

In the field of pathology, understanding the causes of marked bleeding is crucial for diagnosing various conditions. Here is a concise explanation of the options provided:

• VMA disease: There is no well-known condition called VMA disease linked to bleeding disorders. VMA generally refers to vanillylmandelic acid, a metabolite relevant in diagnosing catecholamine-secreting tumors.
• Haemophilia A: This is a genetic disorder caused by missing or insufficient factor VIII, leading to prolonged bleeding episodes. While significant bleeding can occur, it is not typically called "marked" bleeding except in severe cases.
• Haemophilia B: Similar to Haemophilia A, this disorder results from deficiency in factor IX and causes extended bleeding, but again, not typically termed as "marked" for all cases.
• ALL (Acute Lymphoblastic Leukemia): This is a type of cancer involving the blood and bone marrow, characterized by the overproduction of immature lymphoblasts. One of the hallmark symptoms of ALL is marked bleeding due to thrombocytopenia — a low platelet count, causing increased bleeding tendencies.

Thus, marked bleeding is most prominently seen in ALL (Acute Lymphoblastic Leukemia) due to its profound impact on platelet counts and hemostatic functions.