Question

Match the following:

• A. A-IV, B-I, C-II, D-II
• B. A-III, B-I, C-IV, D-II % Option (3) A-III, B-IV, C-II, D-I
• C. A-III, B-IV, C-II, D-I
• D. A-I, B-III, C-IV, D-II

Hint:

Genetic disorders are often linked to specific chromosomes. Understanding their chromosomal location helps in genetic diagnosis and therapy.

Answer 1

The Correct Option is C

To solve the problem, we need to match the diseases with the correct chromosome locations based on the provided information.

1. Understanding the Diseases and Their Chromosome Locations:
(A) Sickle cell anemia: This disease is associated with a mutation in the gene for hemoglobin, which is located on chromosome 11.
(B) Phenylketonuria: This disease is due to a defect in the gene responsible for breaking down phenylalanine, located on chromosome 12.
(C) Cystic fibrosis: This genetic disorder, which affects the lungs and digestive system, is caused by mutations in the CFTR gene on chromosome 7.
(D) α-Thalassemia: This disease is associated with a mutation in the α-globin gene, located on chromosome 16.

2. Analyzing the Options:
(1) A-IV, B-I, C-II, D-III: This option is incorrect as the diseases are not matching the correct chromosome numbers.
(2) A-III, B-I, C-IV, D-II: This option is incorrect because the chromosomes are mismatched for certain diseases.
(3) A-III, B-IV, C-II, D-I: This is the correct answer. Sickle cell anemia is on chromosome 11, Phenylketonuria is on chromosome 12, Cystic fibrosis is on chromosome 7, and α-Thalassemia is on chromosome 16.
(4) A-I, B-III, C-IV, D-II: This option is incorrect as the chromosome numbers do not match the diseases correctly.

3. Identifying the Correct Answer:
The correct matching of diseases to their chromosome locations is A-III, B-IV, C-II, D-I.

Final Answer:
The correct answer is Option C: A-III, B-IV, C-II, D-I.