Question

In one of the following sulfonamides, pyrimidine ring is absent. Which is it?

• A. \( \text{sulfosimidine} \)
• B. \( \text{sulfadimidine} \)
• C. \( \text{sulfadoxine} \)
• D. \( \text{sulfisoxazole} \)

Hint:

Sulfonamides work by inhibiting folic acid synthesis, an essential pathway in bacterial survival.

Answer 1

The Correct Option is D

Sulfonamides are antimicrobial agents, many of which contain pyrimidine rings for enhanced activity. Sulfisoxazole lacks a pyrimidine ring, distinguishing it from other sulfonamides listed in the options. Its structure contains an isoxazole ring instead, which affects its pharmacological properties.