Question

In LC-MS instrument, interface is applied between:

• A. \( \text{LC column and mass separator} \)
• B. \( \text{Injection and ion source} \)
• C. \( \text{LC column and ion source} \)
• D. \( \text{LC column and detector} \)

Hint:

LC-MS coupling requires specialized interfaces to preserve sample integrity and ensure effective ionization.

Answer 1

The Correct Option is C

LC-MS interfaces bridge liquid chromatography (LC) and mass spectrometry (MS), ensuring efficient analyte transfer. The interface is placed between LC column and ion source, converting liquid-phase analytes into gas-phase ions. This transition enables mass spectrometric detection.