\( -12 \)
Step 1: Identify the Required Conditions
A circle that passes through the extremities of the diameter of given circles satisfies the radical axis equation of those circles.
Step 2: Find the Radical Axis
The given circles are:
1. \( x^2 + y^2 = 4 \)
2. \( x^2 + y^2 - 6x - 8y + 10 = 0 \)
3. \( x^2 + y^2 + 2x - 4y - 2 = 0 \)
Subtracting Equation 1 from Equation 2:
\[ (x^2 + y^2 - 6x - 8y + 10) - (x^2 + y^2 - 4) = 0. \]
\[ -6x - 8y + 14 = 0. \]
\[ 6x + 8y = 14. \]
Dividing by 2:
\[ 3x + 4y = 7. \]
This represents the radical axis.
Similarly, subtracting Equation 1 from Equation 3:
\[ (x^2 + y^2 + 2x - 4y - 2) - (x^2 + y^2 - 4) = 0. \]
\[ 2x - 4y + 2 = 0. \]
\[ 2x - 4y = -2. \]
Dividing by 2:
\[ x - 2y = -1. \]
Solving these two equations:
\[ 3x + 4y = 7. \]
\[ x - 2y = -1. \]
Multiplying the second equation by 3:
\[ 3x - 6y = -3. \]
Subtracting:
\[ 10y = 10 \Rightarrow y = 1. \]
Substituting in \( x - 2y = -1 \):
\[ x - 2(1) = -1. \]
\[ x = 1. \]
Thus, the centre of the required circle is \( (1,1) \).
Step 3: Find the Equation of the Required Circle
Since the required circle must be of the form:
\[ x^2 + y^2 + 2gx + 2fy + c = 0, \]
with centre \( (-g, -f) = (1,1) \), we get:
\[ g = -1, \quad f = -1. \]
From the given equations, the radius conditions lead to \( c = -7 \).
\[ g + f + c = -1 - 1 - 7 = -9. \]
Step 4: Conclusion
Thus, the correct answer is:
\[ \mathbf{-9} \]
In the given figure, the numbers associated with the rectangle, triangle, and ellipse are 1, 2, and 3, respectively. Which one among the given options is the most appropriate combination of \( P \), \( Q \), and \( R \)?

The center of a circle $ C $ is at the center of the ellipse $ E: \frac{x^2}{a^2} + \frac{y^2}{b^2} = 1 $, where $ a>b $. Let $ C $ pass through the foci $ F_1 $ and $ F_2 $ of $ E $ such that the circle $ C $ and the ellipse $ E $ intersect at four points. Let $ P $ be one of these four points. If the area of the triangle $ PF_1F_2 $ is 30 and the length of the major axis of $ E $ is 17, then the distance between the foci of $ E $ is:
In a messenger RNA molecule, untranslated regions (UTRs) are present at:
I. 5' end before start codon
II. 3' end after stop codon
III. 3' end before stop codon
IV. 5' end after start codon