Step 1: {Write the direction ratios from the given line equation}
The given line is:
\[
\frac{x - 1}{2} = -y = \frac{2z + 1}{6}.
\]
Equating these to a parameter \( t \), we get:
\[
x - 1 = 2t, \quad y = -t, \quad 2z + 1 = 6t.
\]
Step 2: {Find the direction ratios}
From \( x = 2t + 1 \), \( y = -t \), and \( z = 3t - \frac{1}{2} \), the direction ratios of the line are:
\[
2, -1, 3.
\]
Conclusion: The direction ratios are \( 2, -1, 3 \).