Question

Choose the WRONG statement about mass spectrometry with ESI.

• A. \( \text{It is very unlikely for adducts to occur during ESI.} \)
• B. \( \text{ESI can be used for thermally labile analytes.} \)
• C. \( \text{Adjusting the pH might enhance the generation of ions.} \)
• D. \( \text{It has easy compatibility with LC.} \)

Hint:

ESI facilitates ionization of biomolecules while allowing soft ionization without fragmentation.

Answer 1

The Correct Option is A

Electrospray Ionization (ESI) often forms adducts, such as Na\( ^+ \) or K\( ^+ \), influencing mass spectra interpretation. It is suitable for thermally labile compounds, enhances ion formation via pH adjustment, and integrates efficiently with LC-MS workflows. Thus, statement (A) is incorrect.