Chloride level in sweat is used in the diagnosis of which disease?
Chloride level in sweat is used in the diagnosis of which disease?
- Phenylketonuria
Cystic fibrosis
Gaucher's disease
Osteogenesis imperfecta
The Correct Option is B
Solution and Explanation
The chloride level in sweat is a diagnostic indicator for cystic fibrosis. This condition is a genetic disorder that affects the respiratory and digestive systems. By performing a sweat test, which measures the concentration of chloride excreted in sweat, healthcare professionals can diagnose cystic fibrosis. An elevated chloride level typically indicates a positive result for the disease.
Explanation:
- Phenylketonuria: A metabolic disorder unrelated to sweat chloride levels; diagnosed through blood tests detecting phenylalanine levels.
- Cystic fibrosis: The sweat test reveals high chloride content, indicative of CFTR protein defects causing imbalance, leading to cystic fibrosis.
- Gaucher's disease: A lysosomal storage disorder diagnosed by enzyme activity measurements or genetic testing, not sweat tests.
- Osteogenesis imperfecta: Characterized by bone fragility, diagnosed based on clinical evaluation and genetic testing, not sweat chloride levels.
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