Question:

The most common site of metastasis for breast cancer is:

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In breast cancer, think “BLB” — Bone, Liver, Brain as common metastasis sites, with Bone being the most frequent.
Updated On: Aug 25, 2025
  • Brain
  • Liver
  • Bone
  • Lung
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The Correct Option is C

Approach Solution - 1

The most common site of metastasis for breast cancer is: Bone

When discussing breast cancer, it is important to understand how it can spread to other parts of the body, a process known as metastasis. Metastasis occurs when cancer cells break away from the original tumor in the breast and travel through the body via the bloodstream or lymphatic system. There are several common sites where breast cancer may metastasize
The options provided include:

  • Brain
  • Liver
  • Bone
  • Lung

Among these, the bone is the most frequent site of metastasis for breast cancer. This occurs because breast cancer cells have an affinity for the bone microenvironment, where they can find growth factors that promote their proliferation. Understanding the tendency of breast cancer to metastasize to bone is crucial for developing strategies for surveillance and treatment of patients who may be at risk for such progression. Early detection of metastasis is vital for providing effective care and improving patient outcomes.

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Approach Solution -2

In cases of breast cancer, metastasis refers to the spread of cancer cells from the primary site (breast) to other parts of the body. It is crucial to recognize the common sites where these metastasized cells typically travel. The options provided are Brain, Liver, Bone, and Lung.

Metastasis occurs when cancer cells break away from the original tumor and travel through the bloodstream or lymphatic system to form new tumors in other organs. For breast cancer, the most frequent site of metastasis is the bone.

This is due to the fact that the bone provides a favorable environment for cancer cells to lodge and grow, partly because of the microenvironment in the bone marrow which supports cancer cell survival and proliferation.

Therefore, the correct answer, supported by medical studies, is Bone.

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