Question

About DNA polymerase I which one is correct?

• A. Not required in bacteria
• B. Repair any damage with DNA
• C. Involved in okazaki fragment
• D. Participate in DNA replication

Answer 1

The Correct Option is A

DNA polymerase I is an enzyme involved in several functions related to DNA metabolism. However, it is primarily known for its role in the repair and replication of DNA. Let's analyze each option:

• Not required in bacteria: This statement is incorrect. DNA polymerase I plays a critical role in bacterial DNA processes, particularly in Escherichia coli.
• Repair any damage with DNA: This statement is correct. DNA polymerase I is involved in DNA repair mechanisms by excising RNA primers and filling the gaps with DNA nucleotides during DNA replication and repair.
• Involved in okazaki fragment: This is also correct. DNA polymerase I removes the RNA primers from Okazaki fragments during the lagging strand synthesis and replaces them with DNA.
• Participate in DNA replication: This statement is correct. Although not the main enzyme for DNA elongation, DNA polymerase I participates in DNA replication by processing Okazaki fragments.

Thus, the correct statement related to the DNA polymerase I functionality in the provided options is the involvement in DNA repair and fragmentation processes, making all options except 'Not required in bacteria' correct. Therefore, the wrong assumption here is that DNA polymerase I is not needed in bacteria, when in fact, it is essential.