List of top Pharmaceutical Chemistry Questions asked in GPAT

Methotrexate, used as an antimetabolite, is a product of N-methylation of para-aminobenzoic acid and pyridine hydroxyl. The isosteric group is
Which anemia is caused due to Microcytic, hypochromic red blood cells?
In Baeyer strain theory, which cycloalkane is more stable?
A/B Trans steroidal hydrogen in the 5th position
Match the following disease with their test for detection:
DiseaseDiagnostic tests
P.Tuberculosis(i)Lepromin test
Q.AIDS(ii)ELISA
R.Syphilis(iii)Mantoux test
S.Leprosy(iv)Kahn's test
In a homologous series of any general anesthetic, increasing the chain length increases the lipid solubility and produces a corresponding increase in anesthetic potency, is proposed by:
Tetracycline undergoes epimerization at C4 between pH 4-8 to give:
5-Fluorouracil, an anti-metabolite used in cancer treatment, is activated to:
Match the following antibodies with their correct description:
AntibodyDescription
P. IgE(i) Cross the placenta
Q. IgG(ii) Dominant antibody produced in immune responses
R. IgM(iii) It is found in the mother's milk
S. IgA(iv) Responsible for autoimmune responses including allergies
In a homologous series of any general anesthetic, increasing the chain length increases the lipid solubility, and produce a corresponding increase in anesthetic potency, is proposed by:
The fluoroquinolones act by:
Which ring of warfarin is essential for its therapeutic activity:
Tetracycline undergoes epimerization at C4 between pH 4-8 to give:
Examples of BCS class III drugs are:
5-Fluorouracil, an anti-metabolite used in cancer treatment, is activated to:
Which ring of warfarin is essential for its therapeutic activity:
Which of the following drug does NOT require therapeutic drug monitoring:
Which of the following drug does NOT require therapeutic drug monitoring:
Examples of BCS class III drugs are:
The fluoroquinolones act by:
Select the correct set of anticancer drugs that belong to “pyrimidine and related compounds”:
Which metabolite is used to inactivate the vasico-toxic metabolite leading to hemorrhagic cystitis by alkylating agent used in the treatment of cancer
Which of the following is a 4th Generation Cephalosporin?
What do you mean by Orphan Drug?
Which of the following is NOT an example of an mTOR inhibitor?