Question

Which of the following is NOT an example of an mTOR inhibitor?

• A. Everolimus
• B. Tacrolimus
• C. Temsirolimus
• D. Sirolimus

Answer 1

The Correct Option is A

To determine which option is NOT an example of an mTOR inhibitor, we need to analyze each of the provided options based on their pharmacological classifications:

1. Everolimus: This is, in fact, an mTOR inhibitor. It is commonly used for treating certain cancers and preventing organ transplant rejection.
2. Tacrolimus: This is primarily an immunosuppressant used to prevent organ rejection post-transplantation. It works by inhibiting calcineurin, not mTOR.
3. Temsirolimus: This is a derivative of sirolimus and acts as an mTOR inhibitor, mainly used in cancer therapy.
4. Sirolimus: Known also as rapamycin, sirolimus is an mTOR inhibitor used for prevention of organ transplant rejection and cancer treatment.

Given the above analysis:

• Everolimus is, in reality, an mTOR inhibitor. Thus, it cannot be the correct answer to the question of selecting the one which is NOT an mTOR inhibitor.
• The correct answer based on the list and logical process of elimination is Tacrolimus, as it does not act as an mTOR inhibitor.

Therefore, the correct answer to the question is Tacrolimus, not Everolimus as given in the original answer.