Question

Why do neoplastic cells utilize Warburg metabolism?

• A. It decreases glucose utilization by neoplastic cells
• B. It forms metabolic intermediates which are needed for cell growth and multiplication
• C. It provides more energy in the form of increased ATP production
• D. In prevents apoptosis and makes the cancer immortal

Answer 1

The Correct Option is B

Neoplastic cells, or cancer cells, have been observed to predominantly utilize a unique metabolic process known as the Warburg metabolism (effect). This involves the preference for aerobic glycolysis, a form of metabolism where glucose is converted into lactate even in the presence of ample oxygen. The primary reason neoplastic cells use Warburg metabolism is the formation of metabolic intermediates that are crucial for rapid cell growth and multiplication. During glycolysis, various carbon intermediates are generated. These intermediates are necessary for synthesizing nucleotides, amino acids, and lipids, which are vital for the biosynthesis of macromolecules required in cancer cell proliferation.

Potential Benefits of Warburg Metabolism in Neoplastic Cells
Formation of metabolic intermediates for biosynthesis
Adaptation of the tumor microenvironment
Increased glucose uptake supporting proliferation demands

This metabolic adaptation is not primarily about energy efficiency, as aerobic glycolysis produces less ATP compared to oxidative phosphorylation. Instead, it is about reallocating resources to facilitate and sustain rapid neoplastic growth by providing the building blocks necessary for cell division and growth.

Correct Answer: It forms metabolic intermediates which are needed for cell growth and multiplication.