Question:
Which one of the following programs is used for finding distantly related (or remote) protein homologs?
Which one of the following programs is used for finding distantly related (or remote) protein homologs?
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- BLASTN: DNA vs DNA
- BLASTX: DNA translated vs protein
- TBLASTX: translated DNA vs translated DNA
- PSI-BLAST: best for distantly related proteins.
- BLASTX: DNA translated vs protein
- TBLASTX: translated DNA vs translated DNA
- PSI-BLAST: best for distantly related proteins.
Updated On: Aug 26, 2025
- BLASTN
- BLASTX
- PSI-BLAST
- TBLASTX
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The Correct Option is C
Solution and Explanation
Step 1: BLAST (Basic Local Alignment Search Tool) is used to compare biological sequences.
Step 2: PSI-BLAST (Position-Specific Iterated BLAST) improves sensitivity by building a position-specific scoring matrix (PSSM) from multiple sequence alignments.
Step 3: This allows PSI-BLAST to detect distantly related protein homologs that might not be found by a standard BLAST search.
Final Answer: PSI-BLAST is the program used to find remote protein homologs.
\[\boxed{\text{Correct Answer: (C)}}\]
Step 2: PSI-BLAST (Position-Specific Iterated BLAST) improves sensitivity by building a position-specific scoring matrix (PSSM) from multiple sequence alignments.
Step 3: This allows PSI-BLAST to detect distantly related protein homologs that might not be found by a standard BLAST search.
Final Answer: PSI-BLAST is the program used to find remote protein homologs.
\[\boxed{\text{Correct Answer: (C)}}\]
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