Question:

Which one of the following is used for global alignment of two protein sequences?

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- Global alignment: Needleman-Wunsch.
- Local alignment: Smith-Waterman.
- Structure prediction: Chou-Fasman, GOR.
Updated On: Aug 26, 2025
  • Chou-Fasman method
  • Garnier-Osguthorpe-Robson (GOR) method
  • Needleman-Wunsch algorithm
  • Smith-Waterman algorithm
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The Correct Option is C

Solution and Explanation

Step 1: Global alignment compares sequences over their entire length.
Step 2: The Needleman-Wunsch algorithm is the classic dynamic programming algorithm for global alignment.
Step 3: The Smith-Waterman algorithm, in contrast, is for local alignment.
Step 4: Chou-Fasman and GOR are methods for secondary structure prediction, not sequence alignment.
Final Answer: Needleman-Wunsch algorithm is used for global alignment.
\[\boxed{\text{Correct Answer: (C)}}\]
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