Question

Which of these is a post-translational modification in collagen biosynthesis?

• A. mRNA formation
• B. Peptide bond formation
• C. Glycosylation
• D. Transcription

Hint:

Glycosylation is crucial in collagen biosynthesis as it stabilizes the triple helix structure, which is essential for collagen's functional role in connective tissues.

Answer 1

The Correct Option is C

Step 1: Understanding Post-translational Modifications
Post-translational modifications (PTMs) are chemical modifications made to proteins after they are synthesized. These modifications alter protein function, activity, or structure, and they are crucial for proper protein folding and function.

Step 2: Collagen Biosynthesis and PTMs
In collagen biosynthesis, glycosylation occurs after the collagen polypeptides are synthesized. This involves adding sugar molecules (glycans) to the collagen polypeptides, which enhances the stability and structural integrity of collagen, particularly during the formation of the triple helix structure.

Step 3: Conclusion
Therefore, the correct post-translational modification in collagen biosynthesis is glycosylation, as it directly influences collagen's ability to form a stable structure.