Question

Defective cross-linking of collagen results in:

• A. Marfan syndrome
• B. Lathyrism
• C. Fibrosis
• D. Osteogenesis imperfecta

Hint:

Lathyrism is a rare condition caused by the inhibition of lysyl oxidase, leading to defective collagen cross-linking. The ingestion of Lathyrus sativus can trigger this disorder.

Answer 1

The Correct Option is B

Collagen cross-linking is essential for the strength and integrity of connective tissues. When cross-linking is defective, it can lead to a condition called lathyrism, which is caused by the consumption of certain legumes (such as Lathyrus sativus), which inhibit the enzyme lysyl oxidase. Lysyl oxidase is responsible for facilitating the formation of covalent cross-links between collagen molecules, making them more stable and resistant to mechanical stress. Lathyrism causes weakening of the connective tissues, including ligaments, tendons, and bones, leading to symptoms such as joint stiffness, bone deformities, and vascular problems. While Marfan syndrome and osteogenesis imperfecta are genetic disorders affecting connective tissue, they result from mutations in other proteins (fibrillin-1 in Marfan syndrome and collagen type I in osteogenesis imperfecta) rather than defective collagen cross-linking. Defective collagen cross-linking in lathyrism weakens the structural integrity of tissues, causing significant morbidity in affected individuals.