Question

Which of the following is TRUE for metformin?

• A. \( \text{It is significantly metabolized in the liver} \)
• B. \( \text{Food intake increases its extent of absorption} \)
• C. \( \text{It causes weight gain} \)
• D. \( \text{It exhibits extensive plasma protein binding} \)

Hint:

While the primary exit route for metformin is the kidneys, remember the liver handles a tiny bit of the breakdown. Think "mostly kidney, barely liver."

Answer 1

The Correct Option is A

Metformin's primary elimination pathway is renal excretion of the unchanged drug. Hepatic metabolism is minimal, involving minor pathways. Therefore, the statement that it is *significantly* metabolized in the liver is generally considered FALSE. There appears to be an error in the provided correct answer based on standard pharmacological knowledge. Options B, C, and D are definitively false. Given the options, and the slight involvement of the liver in minor metabolic pathways, option A is the *least* incorrect, although not entirely accurate.