Question

Which of the following is not a method for solubility enhancement:

• A. Crystallization
• B. Co-solvency
• C. Salt formation
• D. Hydrotropy

Hint:

When enhancing solubility, consider using co-solvency (using multiple solvents), salt formation (converting the drug into a more soluble salt), or hydrotropy (using a solubilizing agent) rather than crystallization.

Answer 1

The Correct Option is A

Crystallization is not a method for solubility enhancement. In fact, crystallization is typically used to purify compounds and reduce solubility in a solvent. In contrast, co-solvency, salt formation, and hydrotropy are methods used to improve the solubility of poorly soluble drugs.