Crystallization is not a method for solubility enhancement. In fact, crystallization is typically used to purify compounds and reduce solubility in a solvent. In contrast, co-solvency, salt formation, and hydrotropy are methods used to improve the solubility of poorly soluble drugs.
| Solvent | Boiling Point (K) |
|---|---|
| Chloroform | 334.4 |
| Diethyl Ether | 307.8 |
| Benzene | 353.3 |
| Carbon disulphide | 319.4 |